DNA Alzheimer’s Disease Risk Test

Does late-onset Alzheimer’s disease run in your family? Find out if you are at risk with this DNA Test.____

Detects the APOE e4 variant strongly linked to late-onset Alzheimer’s
Individuals with the variant have a 3X to 15X increased risk
100% private and confidential online results
Are you at increased risk of Alzheimer’s disease?

Collection method: Buccal swab

$195.00

Detailed Description

Alzheimer’s disease (AD) is a progressive brain disorder that gradually destroys memory and other important mental functions. More than 90% of AD cases are the late-onset form, with symptoms not appearing until after 65 years of age.

Two abnormal structures, plaques and tangles, are detected in affected brains. These are the prime suspects for increasing cell death and tissue loss.

Plaques, made of a protein called beta-amyloid, stop the nerve cells from talking to each other. Tangles form when tau, a protein that normally forms parallel strings inside nerve cells, crumbles down into a twisted mess. Without the proper tau tracks, cells are unable to move nutrients and other essential supplies around.

The build up of plaques and tangles are responsible for the cell death, as seen in AD brains. Take this test to find out whether you are at risk, so you can start making changes to keep your brain healthy.

The Genetics

Variation in the APOE gene is the strongest genetic factor influencing the risk of late-onset AD. This gene encodes apolipoprotein E, which is involved in transporting fats, neuronal growth, nerve regeneration, immunoregulation and injury repair in the central nervous system.

Genetic variants identified in this test

There are three common variants (alleles) of APOE, known as e2, e3 and e4. Each of us inherits two copies of the APOE gene. The APOE genotype indicates our risk of late-onset AD:

e2/e2 – reduced risk
e2/e3 – reduced risk
e2/e4 – 3X increased risk
e3/e3 – does not affect your risk
e3/e4 – 3X increased risk
e4/e4 – 10X to 15X increased risk

Understanding your genetic risk for AD can encourage early monitoring and allow drug treatment to begin as soon as possible to delay the progression of the disease.

Warning signs of Alzheimer’s disease

Memory loss that disturbs daily life
Challenges in planning or solving problems
Difficulty performing familiar tasks
Confusion with time or place
Trouble understanding visual images or spatial relationships
New problems with words in speaking or writing
Misplacing things and losing the ability to retrace steps
Decreased or poor judgement
Withdrawals from work or social activities
Changes in mood or personality
On the positive side warrior gene carriers are
Better at making risky financial decisions

Genetic variants identified in this test

There are three common variants (alleles) of APOE, known as e2, e3 and e4. Each of us inherits two copies of the APOE gene. The APOE genotype indicates our risk of late-onset AD:

e2/e2 – reduced risk
e2/e3 – reduced risk
e2/e4 – 3X increased risk
e3/e3 – does not affect your risk
e3/e4 – 3X increased risk
e4/e4 – 10X to 15X increased risk

Understanding your genetic risk for AD can encourage early monitoring and allow drug treatment to begin as soon as possible to delay the progression of the disease.

Warning signs of Alzheimer’s disease

Memory loss that disturbs daily life
Challenges in planning or solving problems
Difficulty performing familiar tasks
Confusion with time or place
Trouble understanding visual images or spatial relationships
New problems with words in speaking or writing
Misplacing things and losing the ability to retrace steps
Decreased or poor judgement
Withdrawals from work or social activities
Changes in mood or personality
On the positive side warrior gene carriers are
Better at making risky financial decisions

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How It Works

Order your test

Choose the test that matches your need from our large array of tests. The kit will be delivered to your doorstep. There is no need to leave the comfort of your home.

Collect your sample

Register and activate your test. Collect your sample. Return your sample to our lab as soon as possible, using the prepaid envelope included in the kit.

Quality guarantee

Your sample will be tested as soon as it arrives in our lab. Your results will be available through our secure online platform.